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Legal steroids or alternatives of anabolic steroid have made the substitutes for Anavar and Winstrolmore stable in terms of the hormonal alterations, but they seem to have produced little long term improvement. [7] The steroid analogue of Winstrol, which is an alpha 1,3-nortestosterone analogue, has shown mixed effects on the pituitary gland in animals. These effects were observed in the same animals with or without anabolic steroids (1.25 % increase in testosterone by Winstrol) [2] [24] [25]. Although further research into the influence of Winstrol on the hypothalamic-pituitary-ovarian axis has not been done, the findings of animal research indicate that Winstrol does not exert its anabolic activities on this axis or to any significant degree. There is evidence that the Winstrol in Winstrol (Wistar) tablet might contribute to the reduction of endogenous anabolic signalling in the hypothalamus of rats through increased mRNA, protein and protein subunit expression. [26] The synthetic steroid nandrolone and nandrolone decanoate are believed to modify the hypothalamic-pituitary-ovarian axis through stimulation of hypothalamic pituitaries with nandrolone and nandrolone decanoate. Nandrolone suppresses LH secretion in rats when administered i.p. to the animals within 24 – 48 hours after it has been given to the animals as a treatment. The effects on LH secretion in the present study are consistent with the action of nandrolone on the pituitary in the hypothalamus of rats. [7] It is not known as yet whether Winstrol is anabolic or anabolic/androgenic or what the effects of the synthetic hormone in the hypothalamus of male rats are after administration. It is generally accepted that all steroid hormones, not including the hormones of reproductive hormone secretion and androgen action, bind to receptors in cells of the pituitary gland and induce anabolic effects. It was suggested, for example, that the synthetic hormones allosteric modulators are anabolic hormones for the pituitary [7] [27]. It is accepted that, as a result of a specific effect under one of its binding sites on the androgen receptor, steroids can reduce androgen sensitivity [28]. Steroids with different ligands at the androgen receptor inhibit the binding to the receptors [29]. However, as these receptors are expressed in different tissues, they are not fully understood when it comes to the effects on the hypothalamic Similar articles:


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